Reagents for Organic Synthesis
Adding reagents heterogeneously can deliver significant advantages for the work-up of the reaction mixture, the so-called downstream processing: isolation and purification of the target compounds usually become simpler, less costly, and making the overall process “greener“ and more sustainable.
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SiliCycle’s competencies around ultrapure silica and the functionalization thereof can support this trend within the chemical and pharmaceutical industry in an excellent way, by offering immobilized reagents.
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SiliaBond Reagents
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Our offer ranges from immobilized aluminium chloride as the classic Lewis acid, heterogeneous palladium and platinum catalysts, to immobilized DMAP (dimethylamino pyridine) as nucleophilec reagent.
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A great number of reactions can benefit from a heterogeneous approach, to name the following as examples: acylation, alkylation, amide/peptide synthesis, reductive amination, debenzylation, hydrogenation, hydrosilylation, and oxidation.
Collaborative work with academic and commercial partners has proven that our SiliaBond and SiliaCat products can generate impressive results in a large number of organic reactions of technical importance.
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A detailed presentation of the SiliaBond reagents and their applications can be found in our designated brochure "Solutions for Organic Synthesis".
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Further details on our SiliaBond Reagents are available to you here on the according webpages from SiliCycle. There you will find a selection guide for our SiliaBond Reagents and Oxidants, and descriptions of all the reactions that can benefit from using our respective products.
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SiliaCat Catalysts
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Most probably, palladium is still the most significant catalyst in organic synthesis, facilitating important reactions like hydrogenations and the important C-C coupling reactions (Heck, Suzuki, Sonogashira, …). Platinum plays in the same league. The well-known advantages of a heterogeneous reaction pathway are also valid here. This made SiliCycle create the brand name of SiliaCat and develop heterogeneous Pd and Pt catalysts.
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A detailed presentation of the SiliaCat catalysts and their applications can be found in our designated brochure "SiliaCat Heterogeneous Catalysts Experimental Procedure".
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